There are mx5 based kits out there so its been done before although on Zeros, MEVs, Westfields, roadrunners etc. Im not sure about the 2B though.
The knowledge is out there on this forum and others no doubt. Id say that if youre looking to use the engine and box it might be worth looking at the diff etc too incase the rotational drive is different.
Has your car already gone through the IVA or older SVA, or are you looking at a rolling chassis stage.